. 2019 Oct 14;8(11):1447–1454. doi: 10.1530/EC-19-0429
This work is licensed under a Table 2.
Mean levels of mineral metabolism and hemostatic biomarkers before and after supplementation.
| Baseline (s.d.) | After supplementation (s.d.) | Absolute difference (95% CI) | P value | |
|---|---|---|---|---|
| 25D, nmol/L | 17.9 (4.6) | 62.5 (20.7) | +44.5 (+38.8 to +50.3) | <0.001 |
| PTH, pmol/L | 7.6 (2.9) | 6.2 (2.5) | −1.4 (−0.7 to −2.1) | <0.001 |
| Calcium, mmol/L | 2.29 (0.08) | 2.29 (0.08) | 0.00 (−0.02 to 0.02) | 0.72 |
| Thrombin generation | ||||
| ETP, nM × min | 1384.3 (218.4) | 1288.9 (197.2) | −95.4 (−127.9 to −62.8) | <0.001 |
| Peak, nM | 221.5 (46.5) | 206.5 (45.7) | −15.1 (−23.3 to −6.8) | <0.001 |
| Lag time, min | 2.99 (0.50) | 3.24 (0.53) | +0.25 (+0.12 to +0.37) | <0.001 |
| Time to peak, min | 6.41 (0.98) | 6.63 (0.92) | +0.22 (+0.03 to +0.41) | 0.027 |
| Fibrinolysis | ||||
| Clot lysis time, mina | 16.6 (5.5) | 17.0 (6.6) | +0.4 (−1.3 to +2.1) | 0.62 |
| Fibrin polymerization | ||||
| Maximum absorbance, ODa | 0.43 (0.08) | 0.40 (0.08) | −0.04 (−0.06 to −0.02) | 0.001 |
| Other | ||||
| Prothrombin time, % | 92.3 (8.6) | 91.9% (8.6) | −0.4 (−2.2 to 1.4) | 0.65 |
| aPTT, s | 30.0 (3.2) | 30.0 (3.2) | 0.0 (−0.5 to 0.5) | 0.95 |
| Fibrinogen activity, g/L | 3.1 (0.7) | 3.0 (0.7) | 0.0 (−0.2 to 0.1) | 0.64 |
| PAI-1 | 12.9 (8.0) | 14.0 (13.0) | +1.1 (−1.7 to + 3.9) | 0.42 |
| Homocysteineb | 14.7 (14.8) | 12.0 (4.9) | −2.7 (−6.4 to +1.1) | 0.15 |
an = 47; bn = 45.
aPTT, activate partial thromboplastin time; ETP, endogenous thrombin potential; OD, optical density; PAI-1, plasminogen activator inhibitor-1.