. 2018 Jan 4;7(2):286–294. doi: 10.1530/EC-17-0313
This work is licensed under a Table 4.
Univariate analysis of risk factors for the development of transient and permanent hypoparathyroidism.
| Variables | No permanent | Permanent (n = 7) | P value† | P value‡ | ||
|---|---|---|---|---|---|---|
| Normal (n = 431) | Transient (n = 264) | Total (n = 695) | ||||
| Age (<45/≥45, years) | 241/190 | 152/112 | 393/302 | 2/5 | 0.694 | 0.250 |
| Gender (male/female) | 138/293 | 53/211 | 191/504 | 1/6 | 0.001 | 0.680 |
| BMI (<25/≥25, kg/m2) | 303/128 | 195/69 | 498/197 | 5/2 | 0.340 | 1 |
| Hypertension | 57 | 26 | 83 | 1 | 0.228 | 0.592 |
| Diabetes | 12 | 6 | 18 | 0 | 0.808 | 1 |
| Thyroiditis | 121 | 78 | 199 | 2 | 0.730 | 1 |
| Graves’ disease | 12 | 8 | 20 | 0 | 0.820 | 1 |
| Hypothyroidism | 5 | 3 | 8 | 0 | 1 | 1 |
| Nodular goiter | 251 | 158 | 409 | 3 | 0.692 | 0.456 |
| Preoperative calcium (mmol/L) | 2.31 ± 0.16 | 2.32 ± 0.44 | 2.31 ± 0.30 | 2.26 ± 0.09 | 0.658 | 0.676 |
| Preoperative PTH (pmol/L) | 5.73 ± 1.98 | 5.28 ± 1.75 | 5.54 ± 1.16 | 4.28 ± 2.33 | 0.145 | 0.129 |
| Surgical extent (UCND/≥BCND) | 172/259 | 79/185 | 251/444 | 2/5 | 0.009 | 1 |
| Largest tumor size (mm) | 13.6 ± 8.4 | 14.6 ± 10.3 | 14.0 ± 9.2 | 14.4 ± 5.4 | 0.223 | 0.832 |
| Multifocality | 101 | 76 | 177 | 2 | 0.127 | 1 |
| Tumor location (upper/middle/lower/isthmus) | 127/174/116/14 | 64/121/70/9 | 191/295/186/23 | 4/3/0/0 | 0.138 | 0.098 |
| T classification (T1–2/T3–4) | 175/256 | 118/146 | 293/402 | 3/4 | 0.304 | 1 |
| N classification (N0/N1) | 166/265 | 94/170 | 260/435 | 2/5 | 0.468 | 1 |
| AJCC stage (I–II/III–IV) | 272/159 | 179/85 | 451/244 | 4/3 | 0.220 | 0.701 |
| Gross extrathyroidal extension | 174 | 106 | 280 | 3 | 1 | 1 |
| Harvested lymph nodes (<10/≥10)* | 205/226 | 107/157 | 312/383 | 5/2 | 0.071 | 0.254 |
| Parathyroid identification (<3/≥3) | 55/376 | 39/225 | 94/601 | 3/4 | 0.493 | 0.059 |
| Parathyroid autotransplantation (0/1) | 220/211 | 96/168 | 316/379 | 3/4 | 0.000 | 1 |
| Inadvertent parathyroidectomy (0/1) | 420/11 | 254/10 | 674/21 | 6/1 | 0.369 | 0.201 |
| Parathyroid preservation (<2/≥2) | 29/402 | 23/241 | 52/643 | 3/4 | 0.373 | 0.013 |
*Central lymph nodes; †normal vs transient; ‡no permanent (total) vs permanent.
AJCC, American Joint Committee on Cancer; BCND, bilateral central neck dissection; BMI, body mass index; PTH, parathyroid hormone; UCND, unilateral central neck dissection.