Table 1. Key epigenetic reader proteins grouped by respective chromatin modification, modification sites and protein binding domain.
| Modification | Modification Site(s) | Binding domain(s) | Reader Protein |
|---|---|---|---|
| Acetylated histone tails | H3: K9, K14, K18, K27, K56, K122 H4: K5, K8, K13, K16 |
BDs | BRD2, BRD3, BRD4, BRDT |
| Methylated CpG | CpG | MBD | MeCP2, MBDs1–6 |
| MBD/ SET | SETDB1, SETDB2 | ||
| MBD/DDT/ PHD/BD |
BAZ2A/B | ||
| Methylated Histones | H3K4 | Chromo | CHD1 |
| PHD | BPTF, TAF3, ING4, CFP1, SPIN1, PHF2/23, PYGO2 | ||
| Tudor | Sgf29 | ||
| H3K9 | Chromo | HP1α/β/γ | |
| Tudor | UHRF1 | ||
| H3K27 | Chromo | CBX7 | |
| WD40 | EED | ||
| BAH | BAHD1 | ||
| PWWP | NSD2 | ||
| H3K36 | PWWP | DNMT3A, LEDGF, ZMYND11 | |
| Chromo | MRG15 | ||
| - | NBS1, Ku70 | ||
| H3K79 | Tudor | TP53BP1 | |
| H4K20 | Tudor | TP53BP1 | |
| MBT | L3MBTL1 | ||
| BAH | ORC1 | ||
| WD repeat | ORCA | ||
| PWWP | PDP1 |
Abbreviations: Histone 3 (H3), Histone 4 (H4), Lysine (K), Methyl-CpG Binding Domain (MBD), Methyl-CpG binding protein 2 (MeCP2), Methyl-CpG Binding Domain Protein 1–6 (MBD1–6), Su(var)3–9, Enhancer-of-zeste and Trithorax (SET), SET Domain Bifurcated Histone Lysine Methyltransferase 1–2 (SETDB1–2), DDT domain, Plant homeodomain (PHD), Bromodomain Adjacent To Zinc Finger Domain 2A/B (BAZ2A/B), Chromodomain Helicase DNA Binding Protein 1 (CHD1), Bromodomain PHD Finger Transcription Factor (BPTF), TATA-Box Binding Protein Associated Factor 3 (TAF3), Inhibitor Of Growth 4 (ING4), CxxC zinc finger protein 1 (CFP1), Spindlin 1 (SPIN1), PHD Finger Protein 2/23 (PHF2/23), Pygopus 2 (PYGO2), SAGA Complex Associated Factor 29 (Sgf29), Heterochromatin Protein 1 α/β/γ (HP1α/β/γ), Ubiquitin Like With PHD And Ring Finger Domains 1 (UHRF1), Chromobox 7 (CBX7), Tryptophan-Aspartic acid 40 (WD40), Embryonic Ectoderm Development (EED), Bromo-Adjacent Homology (BAH), Bromo Adjacent Homology Domain-containing Protein 1 (BAHD1), PWWP domain, Nuclear Receptor Binding SET Domain Protein 2 (NSD2), DNA Methyltransferase 3 Alpha (DNMT3A), Lens Epithelium-Derived Growth Factor (LEDGF), Zinc Finger MYND-Type Containing 11 (ZMYND11), MORF-Related Gene On Chromosome 15 (MRG15), Nijmegen Breakage Syndrome (NBS1), Ku Autoantigen, 70 (Ku70), Tumor Protein P53 Binding Protein 1 (TP53BP1), Malignant Brain Tumor (MBT) domain, Lethal(3) Malignant Brain Tumor-like Protein 1 (L3MBTL1), Origin Recognition Complex Subunit 1 (ORC1), Origin Recognition Complex Associated (ORCA), Pyruvate Dehyrogenase Phosphatase (PDP1).