Fig. 2.

Image along the YZ-plane (100 µm extended) of the spiral ligament of the cochlea from a CX3CR1^+/GFP mouse. Green cells denote resident macrophages. The dotted line represents the spiral ligament, and the dotted area marks the area with a lack of macrophages. (A) Middle turn of an untreated cochlea. (B) Basal turn of an untreated cochlea. (C) Middle turn of an inflamed cochlea. (D) Basal turn of an inflamed cochlea. Compared to the untreated cochlea, the inflamed cochlea shows a higher density of green cells. Newly localized macrophage/monocytes are seen in the basilar membrane and in the spiral limbus of the inflamed cochlea. Notably, the areas adjacent to the stria vascularis and beneath it show very few macrophages.