| 1.1 Incidence of VAP |
13 |
1206 |
Risk Ratio (M‐H, Random, 95% CI) |
0.67 [0.47, 0.97] |
| 1.1.1 Chlorhexidine solution versus placebo (no toothbrushing in either group) |
6 |
429 |
Risk Ratio (M‐H, Random, 95% CI) |
0.57 [0.33, 1.00] |
| 1.1.2 Chlorhexidine gel versus placebo (no toothbrushing in either group) |
2 |
297 |
Risk Ratio (M‐H, Random, 95% CI) |
0.53 [0.29, 0.97] |
| 1.1.3 Chlorhexidine solution versus placebo (toothbrushing both groups) |
3 |
332 |
Risk Ratio (M‐H, Random, 95% CI) |
0.74 [0.29, 1.89] |
| 1.1.4 Chlorhexidine gel versus placebo (toothbrushing both groups) |
2 |
148 |
Risk Ratio (M‐H, Random, 95% CI) |
1.22 [0.83, 1.79] |
| 1.2 Mortality |
9 |
944 |
Risk Ratio (M‐H, Random, 95% CI) |
1.02 [0.84, 1.23] |
| 1.2.1 Chlorhexidine solution versus placebo (no toothbrushing in either group) |
4 |
374 |
Risk Ratio (M‐H, Random, 95% CI) |
1.03 [0.80, 1.33] |
| 1.2.2 Chlorhexidine gel versus placebo (no toothbrushing in either group) |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
Not estimable |
| 1.2.3 Chlorhexidine solution versus placebo (toothbrushing both groups) |
2 |
382 |
Risk Ratio (M‐H, Random, 95% CI) |
1.00 [0.72, 1.40] |
| 1.2.4 Chlorhexidine gel versus placebo (toothbrushing both groups) |
2 |
148 |
Risk Ratio (M‐H, Random, 95% CI) |
1.00 [0.59, 1.68] |
| 1.3 Duration of ventilation (days) |
4 |
594 |
Mean Difference (IV, Random, 95% CI) |
‐1.10 [‐3.20, 1.00] |
| 1.3.1 Chlorhexidine solution versus placebo (no toothbrushing in either group) |
3 |
263 |
Mean Difference (IV, Random, 95% CI) |
‐2.63 [‐3.35, ‐1.90] |
| 1.3.2 Chlorhexidine gel versus placebo (no toothbrushing in either group) |
1 |
257 |
Mean Difference (IV, Random, 95% CI) |
2.21 [‐0.30, 4.72] |
| 1.3.3 Chlorhexidine solution versus placebo (toothbrushing both groups) |
1 |
74 |
Mean Difference (IV, Random, 95% CI) |
‐1.30 [‐4.20, 1.60] |
| 1.4 Duration of ICU stay (days) |
5 |
627 |
Mean Difference (IV, Random, 95% CI) |
‐0.89 [‐3.59, 1.82] |
| 1.4.1 Chlorhexidine solution versus placebo (no toothbrushing in either group) |
3 |
274 |
Mean Difference (IV, Random, 95% CI) |
‐2.92 [‐4.18, ‐1.66] |
| 1.4.2 Chlorhexidine gel versus placebo (no toothbrushing in either group) |
1 |
257 |
Mean Difference (IV, Random, 95% CI) |
1.32 [‐2.43, 5.07] |
| 1.4.3 Chlorhexidine gel versus placebo (toothbrushing both groups) |
1 |
96 |
Mean Difference (IV, Random, 95% CI) |
5.00 [‐2.20, 12.20] |
| 1.5 Duration of systemic antibiotic therapy (days) |
1 |
146 |
Mean Difference (IV, Fixed, 95% CI) |
0.65 [‐0.58, 1.88] |
| 1.5.1 Chlorhexidine solution versus placebo (toothbrushing both groups) |
1 |
146 |
Mean Difference (IV, Fixed, 95% CI) |
0.65 [‐0.58, 1.88] |
| 1.6 Number of participants treated with systemic antibiotics |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.6.1 Chlorhexidine solution versus placebo (no toothbrushing in either group) |
1 |
16 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.86 [0.53, 1.38] |
| 1.7 Plaque index |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.7.1 Chlorhexidine solution versus placebo (no toothbrushing in either group) |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.8 Adverse effects |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.8.1 Reversible mild irritation of oral mucosa |
1 |
207 |
Risk Ratio (M‐H, Fixed, 95% CI) |
10.29 [1.34, 78.97] |
