Table 10.

Infectious Diseases Society of America (IDSA) and Society of Healthcare Epidemiology of America (SHEA) joint guidelines.⁶

Treatment of first recurrence
Vancomycin 125 mg orally given 4 times daily for 10 days if metronidazole was used for the initial episode, OR
Use a prolonged tapered and pulsed vancomycin oral regimen if a standard regimen was used for the initial episode (e.g., 125 mg 4 times per day for 10–14 days, 2 times per day for a week, once per day for a week, and then every 2 or 3 days for 2–8 weeks), OR
Fidaxomicin 200 mg orally given twice daily for 10 days if vancomycin was used for the initial episode

IDSA, Infectious Diseases Society of America; SHEA, Society of Healthcare Epidemiology of America.