Table 8.

Australasian society for infectious Disease.²⁶

Clinical definition	Recommended treatment in adults
Initial episode, non-severe	Metronidazole 400 mg orally TID for 10 days
Initial episode, severe	If oral therapy possible: Oral vancomycin 125 mg QID for 10 days
	If oral therapy not possible: IV metronidazole 400 mg TID with vancomycin 125 mg QID via nasogastric tube with consideration for rectal vancomycin 500 mg in 100 cc normal saline TID or QID
First recurrence	Vancomycin 125 mg orally QID for 10 days
Second or subsequent recurrence	Any of the following:
	Vancomycin 125 mg orally QID for 14 days with or without a taper
	Fidaxomicin 200 mg orally BID for 10 days
	FMT
	Rifaximin chaser 400 mg TID for 7–10 days or 400 mg TID 14–20 days post initial therapy

FMT, fecal microbiota transplantation; IV, intravenous; QID, four times per day; TID, three times per day.