Fig. 2. Schematic representation of the main physico-chemical properties of NPs, such as size, shape, surface functionalization, charge and topography. These properties need to be considered when employing NPs as carriers for drug delivery in nanomedicine. EGF – epidermal growth factor; PEG – polyethylene glycol. Adapted with permission from (a) ref. 421, (b) ref. 422, (c) ref. 423, (d) ref. 424 and (e–h) ref. 154. Copyright (a) Susnik et al. 2020, (b) Kuttner et al. 2018, (c) Madathiparambil Visalakshan et al. 2020, (d) Liu et al. 2015 and (e–h) Singh et al. 2019.