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. 2021 May 10;175(8):1–8. doi: 10.1001/jamapediatrics.2021.0678

Table 1. Comparison of Baseline Characteristics.

Variable No. (%)
Preterm formula fortification (n = 59) Human milk fortifier (n = 63)
Maternal characteristics
Gestational hypertension 2 (3) 4 (6)
Preeclampsia/eclampsia 11 (19) 7 (11)
Umbilical artery doppler changes
AEDF 6 (10) 7 (11)
REDF 9 (15) 9 (14)
Multiple pregnancies 21 (36) 25 (40)
Received antenatal corticosteroids
1 Course 18 (31) 22 (35)
2 Course 6 (10) 8 (13)
Incomplete 31 (53) 31 (49)
Not given 5 (9) 2 (3)
Neonatal characteristics
Gestation, mean (SD), wk 30.5 (2.2) 29.9 (2.2)
Birth weight, mean (SD), g 1161 (251) 1119 (265)
Intrauterine growth
SGA 22 (37) 22 (35)
AGA 38 (64) 40 (64)
Infant sex
Male 29 (49) 39 (62)
IUGR 33 (56) 30 (47.6)
Apgar, median (IQR)
At 1 min 7 (3-7) 7 (3-7)
At 5 min 8 (7-8) 8 (7-8)
Received PN 27 (45) 30 (47)
Age at starting PN, median (IQR), da 1 (1-2) 1 (1-2)
Age at stopping PN, median (IQR), da 8 (6-11) 9 (7-11)
Total duration of PN, median (IQR), da 7 (5-10) 7 (6-10)
Age at initiation of enteral feeds, median (IQR), d 1 (1-3) 2 (1-3)
Age of attainment of enteral intake 100 mL/kg/d, median (IQR), d 4 (2-6.5) 4 (2-9)
Age at enrollment, median (IQR), d 7 (5-10) 8 (4-11)
Weight at enrollment, mean (SD), g 1038 (350) 1074 (323)
Length at enrollment, mean (SD), cm 37.5 (3.8) 36.4 (3.5)
HC at enrollment, mean (SD), cm 26.6 (1.7) 26.2 (2.3)
Mean fluid volume at enrollment, mean (SD), mL/kg/d 144 (17.6) 146 (16)

Abbreviations: AGA, appropriate for gestational age; AEDF, absent end diastolic flow; HC, head circumference; IQR, interquartile range; IUGR, intrauterine growth restriction; LGA, large for gestational age; PN, parenteral nutrition; REDF, reversed end diastolic flow; SGA, small for gestational age.

a

Data shown for neonates who received any parenteral nutrition.