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. 2021 May 10;175(8):1–8. doi: 10.1001/jamapediatrics.2021.0678

Table 3. Comparison of Cost of Fortification With Preterm Formula Powder and HMF.

Study cohort Preterm formula fortification, $ Human milk fortifier fortification, $
Estimated cost of fortification for the study cohorta
Cost of fortification for 1 d for a neonate with fluid intake of 180 mL/kg/d 0.27 4
Estimated costs for the whole cohort 382 8568
Estimated costs for a community health facility for a typical neonate of weight 1.25 kgb
Cost of fortification for 1 infant for a period of 42 d (average duration of hospital stay) 11.3 168
Cost for fortification for 1 y in a NICU with 10 000 deliveries per year, assuming neonates needing fortification to be 250/y (2.5%) 2835 42 000

Abbreviation: HMF, human milk fortifiers.

a

Assuming a uniform feed volume of 180 mL/kg/d throughout the intervention period, ie, the median duration of in-hospital fortification of 24 and 34 days in the PTF and HMF groups, respectively, in the study cohort.

b

Assumptions: average weight of neonate needing fortification is 1.25 kg. Average duration of fortification required is 42 days (7 weeks); proportion of preterm neonates requiring fortification is 2.5%.