Figure 3.

Meta-analysis results including forest plots of (A) RR of ORR, (B) HR of PFS and (C) OS in patients with low TMB assigned to receive first-line IO regimens versus CT.

CI, confidence interval; CT, platinum-based chemotherapy; D, durvalumab; df, degree freedom; HR, hazard ratio; IO, immuno-oncology; IV, inverse variance; M-H, Mantel-Haenszel; ORR, objective response rate; OS, overall survival; PFS, progression-free survival; RR, risk ratio; SE, standard error; T, tremelimumab; TMB, tumor mutational burden.