FIGURE 2.
Cultured TIL (pre-rapid expansion protocol) from fresh soft tissue sarcoma specimens. A, Expansion of CD3+ TIL at a threshold for clinical grade expansion (2×107, dashed line) is possible at 4 weeks for several different histologic subtypes. B, Distribution of TIL culture phenotype from multiple tumor fragments reveals significant heterogeneity. DDLPS indicates dedifferentiated liposarcoma; DSRCT, desmoplastic small round cell tumor; GIST, gastrointestinal stromal tumor; LMS, leiomyosarcoma; MPNST, malignant peripheral nerve sheath tumor; NOS, not otherwise specified; TIL, tumor-infiltrating lymphocyte; UPS, undifferentiated pleomorphic sarcoma; WDLPS, well-differentiated liposarcoma.