Figure 2.

Dose-response relationships of 40,000 HepG2 cells after a 48 h exposure to acetaminophen at atmospheric (20%), periportal (8%), or perivenous (3%) oxygen tensions. Each point is the average and SEM collected from at least two different cell passages (N=2); each pass contained at least three technical replicates (n=3). The black lines connecting the points represent the best-fit 4PL model; the gray shaded regions represent the 95% confidence intervals of those fits.