Skip to main content
. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Toxicol In Vitro. 2021 Mar 31;74:105156. doi: 10.1016/j.tiv.2021.105156

Figure 3.

Figure 3.

Dose-response relationships of 40,000 HepG2 cells in the 3D culture format after a 48 h exposure to either cyclophosphamide (a-c) or aflatoxin B1 (d-f) at atmospheric (20%), periportal (8%), or perivenous (3%) oxygen tensions. Each point is the average and SEM collected from at least two different cell passages (N=2–3); each pass contained at least three technical replicates (n=3). The black lines connecting the points represent the best-fit 4PL model (cyclophosphamide) and 3-PL model (aflatoxin B1); the gray shaded regions represent the 95% confidence intervals of those fits.