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. 2021 May 11;16(5):1156–1164. doi: 10.1016/j.stemcr.2021.01.016

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Apoptosis marker cleaved caspase-3 co-localizes with NP at 14 dpi

(A) Representative confocal images of infected cells show co-localization of NP with cleaved caspase-3 (Asp175) (aCasp3) 14 dpi. In addition, aCasp3 co-localizes with GFAP. DNA fragmentation is not seen.

(B) There is low co-localization of aCasp3 with NP or GFAP 4 dpi.

(C) Quantification of aCasp3 co-localization with NP or GFAP at 4 and 14 dpi. Each point represents the mean of three sections from three organoids. Significant statistical differences are indicated among samples (p < 0.05). N = 3 organoids from two independent experiments.