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. 2021 May 11;16(5):1165–1181. doi: 10.1016/j.stemcr.2021.04.001

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

CD45⁺ CECs from the peripheral blood of COVID-19 patients and human bone marrow exhibit the highest intensity of ACE2 expression compared with other immune cells

(A) Plots showing the expression of ACE2 on CD45⁻ CECs versus CD45⁺ CECs from PBMCs from a COVID-19 patient.

(B) Percentage of ACE2 surface expression on total CECs and immune cell lineages in PBMCs from a COVID-19 patient.

(C) Cumulative data of the percentage of ACE2 expressing cells among different immune cell lineages and CECs in PBMCs from COVID-19 patients.

(D and E) (D) Representative plots and (E) cumulative data of the intensity of ACE2 expression in CD45⁺ CECs, CD45⁻ CECs, and immune cell lineages measured by mean fluorescence intensity (MFI) in PBMCs from COVID-19 patients.

(F) Representative plots of the percentage of ACEs expression in CD45⁻, CD45lo, and CD45hiCECs in PBMCs from COVID-19 patients.

(G) Plot showing the intensity of ACE2 expression in CD45hi, CD45lo, and CD45⁻ CECs compared with isotype control in PBMCs from COVID-19 patients.

(H) Plots showing the expression of ACE2 on CD19 B cells, CD3 T cells, CD16CD56 NK cells, CD14 monocytes, and CECs compared with the isotype control antibody in the bone marrow aspirates of a healthy adult.

(I) Representative plots of the percentage of ACEs expression in CD45⁻, CD45lo, and CD45hiCECs of the bone marrow.

(J) Histogram plot of the intensity of ACE2 expression in CD45hi, CD45lo, and CD45⁻ CECs of the bone marrow compared with isotype control. Each point represents data from one patient. Bar, mean ± 1 standard error.