Supplementary Table 6.
Relative Risk of Hospital Admission, Intensive Care Unit Admission, Mechanical Ventilation, or Death According to Use of the Different Classes of Proton Pump Inhibitors
| Outcome | Lansoprazole |
Pantoprazole |
|||
|---|---|---|---|---|---|
| Events | Risk (%) | Events | Risk (%) | Relative risk | |
| Crude | |||||
| Death | 40/833 | 4.8 (3.3–6.3) | 187/2607 | 7.2 (6.2–8.2) | 0.67 (0.48–0.93) |
| ICU admission | 25/833 | 3.0 (1.8–4.2) | 71/2607 | 2.7 (2.1–3.3) | 1.10 (0.70–1.73) |
| ICU or death | 55/833 | 6.6 (4.9–8.3) | 237/2607 | 9.1 (8.0–10.2) | 0.73 (0.55–0.96) |
| Mechanical ventilation | 12/833 | 1.4 (0.6–2.2) | 41/2607 | 1.6 (1.1–2.1) | 0.92 (0.48–1.73) |
| Hospital admission | 180/833 | 21.6 (18.8–24.4) | 633/2607 | 24.3 (22.6–25.9) | 0.89 (0.77–1.03) |
| Matched | |||||
| Death | 38/829 | 4.6 (3.2–6.0) | 37/829 | 4.5 (3.1–5.9) | 1.03 (0.66–1.60) |
| ICU admission | 24/829 | 2.9 (1.8–4.0) | 23/829 | 2.8 (1.7–3.9) | 1.04 (0.59–1.83) |
| ICU or death | 53/829 | 6.4 (4.7–8.1) | 52/829 | 6.3 (4.6–7.9) | 1.02 (0.70–1.48) |
| Mechanical ventilation | 12/829 | 1.4 (0.6–2.3) | 15/829 | 1.8 (0.9–2.7) | 0.80 (0.38–1.70) |
| Hospital admission | 178/829 | 21.5 (18.7–24.3) | 195/829 | 23.5 (20.6–26.4) | 0.91 (0.76–1.09) |
| Outcome | Omeprazole |
Pantoprazole |
|||
|---|---|---|---|---|---|
| Events | Risk (%) | Events | Risk (%) | Relative risk | |
| Crude | |||||
| Death | 22/749 | 2.9 (1.7–4.1) | 192/2616 | 7.3 (6.3–8.3) | 0.40 (0.26–0.62) |
| ICU admission | 14/749 | 1.9 (0.9–2.8) | 73/2616 | 2.8 (2.2–3.4) | 0.67 (0.38–1.18) |
| ICU or death | 34/749 | 4.5 (3.0–6.0) | 242/2616 | 9.3 (8.1–10.4) | 0.49 (0.35–0.70) |
| Mechanical ventilation | 11/749 | 1.5 (0.6–2.3) | 41/2616 | 1.6 (1.1–2.0) | 0.94 (0.48–1.81) |
| Hospital admission | 126/749 | 16.8 (14.1–19.5) | 640/2616 | 24.5 (22.8–26.1) | 0.69 (0.58–0.82) |
| Matched | |||||
| Death | 22/747 | 2.9 (1.7–4.2) | 37/747 | 5.0 (3.4–6.5) | 0.59 (0.35–1.00) |
| ICU admission | 14/747 | 1.9 (0.9–2.8) | 14/747 | 1.9 (0.9–2.8) | 1.00 (0.48–2.08) |
| ICU or death | 34/747 | 4.6 (3.1–6.0) | 44/747 | 5.9 (4.2–7.6) | 0.77 (0.50–1.19) |
| Mechanical ventilation | 11/747 | 1.5 (0.6–2.3) | 9/747 | 1.2 (0.4–2.0) | 1.22 (0.51–2.93) |
| Hospital admission | 126/747 | 16.9 (14.2–19.6) | 125/747 | 16.7 (14.1–19.4) | 1.01 (0.80–1.26) |
| Outcome | Esomeprazole |
Pantoprazole |
|||
|---|---|---|---|---|---|
| Events | Risk (%) | Events | Risk (%) | Relative risk | |
| Crude | |||||
| Death | 21/324 | 6.5 (3.8–9.2) | 192/2614 | 7.3 (6.3–8.3) | 0.88 (0.57–1.36) |
| ICU admission | 8/324 | 2.5 (0.8–4.2) | 73/2614 | 2.8 (2.2–3.4) | 0.88 (0.43–1.82) |
| ICU or death | 28/324 | 8.6 (5.6–11.7) | 242/2614 | 9.3 (8.1–10.4) | 0.93 (0.64–1.36) |
| Mechanical ventilation | NA | NA | NA | NA | 0.79 (0.28–2.18) |
| Hospital admission | 65/324 | 20.1 (15.7–24.4) | 639/2614 | 24.4 (22.8–26.1) | 0.82 (0.65–1.03) |
| Matched | |||||
| Death | 21/324 | 6.5 (3.8–9.2) | 22/324 | 6.8 (4.1–9.5) | 0.95 (0.54–1.70) |
| ICU admission | 8/324 | 2.5 (0.8–4.2) | 8/324 | 2.5 (0.8–4.2) | 1.00 (0.38–2.63) |
| ICU or death | 28/324 | 8.6 (5.6–11.7) | 27/324 | 8.3 (5.3–11.3) | 1.04 (0.63–1.72) |
| Mechanical ventilation | NA | NA | NA | NA | 0.80 (0.22–2.95) |
| Hospital admission | 65/324 | 20.1 (15.7–24.4) | 63/324 | 19.4 (15.1–23.8) | 1.03 (0.76–1.41) |
ICU, intensive care unit; NA (not applicable), refers to no observed events or number of events below 5 not presented because of patient confidentiality considerations.