Table 2.

Lower grey matter in patients with AUD compared with controls in the meta-analysis

Anatomical regions	MNI coordinates x, y, z	SDM value	p value	Number of voxels	Breakdown
AUD < controls
Right median cingulate / paracingulate gyri (BA24)	2,6,42	−4.438	~ 0	249	Right median cingulate / paracingulate gyri, BA24 Left median cingulate / paracingulate gyri, BA24
Right insula, BA 48	40,0,4	−4.581	0.000010*****	3641	Right insula, BA 48 Right rolandic operculum, BA 48 Right inferior frontal gyrus, opercular part, BA 44,48 Right precentral gyrus, BA 4,6
Left middle frontal gyrus, BA 46	−28,42,30	−3.573	0.00015****	106	Left middle frontal gyrus, BA 46 Left middle frontal gyrus

AUD = Alcohol abuse disorders; MNI = Montreal Neurological Institute; SDM = signed differential mapping; BA = Brodmann area; *****p < 0.00001; ****p < 0.0001