Table 2.
Potential drug targets with relative PIN essentiality and <50% similarity to the human proteome.
| Protein | Description | Similarity* | Coverage* | Number of potential compounds to interact with Leishmania proteins | Number of potential compounds already tested for Leishmania deposited in BindingDB |
|---|---|---|---|---|---|
| LbrM.10.0640 | Glycerol-3-phosphate dehydrogenase (GPHD) | 48.7 | 91.2 | 63 | 8 |
| LbrM.29.2360 | Putative kinesin | 48.7 | 76.1 | 640 | 0 |
| LbrM.30.2040 | Putative alcohol dehydrogenase | 41.0 | 72.2 | 35 | 0 |
| LbrM.35.6570 | Putative small G-protein | 43.7 | 77.5 | 341 | 1 |
| LinJ.02.0710 | Hypothetical Protein - Dipeptylcarboxypeptidase | 45.8 | 83.6 | 42 | 0 |
| LinJ.10.0560 | Glycerol-3-phosphate dehydrogenase (GPHD) | 43.8 | 91.0 | 52 | 0 |
| LinJ.27.1710 | Phosphoenolpyruvate carboxykinase | 46.3 | 13.1 | 22 | 0 |
| LinJ.30.2100 | Putative alcohol dehydrogenase | 43.3 | 89.2 | 9 | 0 |
| LinJ.34.3030 | Putative Alpha-keto-acid decarboxylase | 39.2 | 72.3 | 33 | 0 |
*
Against the Human proteome.