Table 1.
Patients characteristics of MBC patients and IDC patients
| Characteristics | MBC N = 10,593 (%) | IDC N = 402,797 (%) | P |
|---|---|---|---|
| Sex | < 0.001 | ||
| Female | 10,552 (99.6) | 399,699 (99.2) | |
| Male | 41 (0.4) | 3098 (0.8) | |
| Age | < 0.001 | ||
| < 60 years old | 3395 (32.0) | 208,149 (51.7) | |
| ≥ 60 years old | 7198 (68.0) | 194,648 (48.3) | |
| Race | < 0.001 | ||
| White | 8102 (76.5) | 315,613 (78.4) | |
| Black | 1177 (11.1) | 45,881 (11.4) | |
| Other | 1314 (12.4) | 41,303 (10.3) | |
| Marital status | < 0.001 | ||
| Married | 4993 (47.1) | 224,449 (55.7) | |
| Singled | 5054 (47.7) | 158,735 (39.4) | |
| Unknown | 546 (5.2) | 19,613 (4.9) | |
| Location | < 0.001 | ||
| Central portion of breast | 847 (8.0) | 21,247 (5.3) | |
| Upper-inner quadrant | 1232 (11.6) | 48,162 (12.0) | |
| Lower-inner quadrant | 977 (9.2) | 22,735 (5.6) | |
| Upper-outer quadrant | 5318 (50.2) | 229,970 (57.1) | |
| Lower-outer quadrant | 938 (8.9) | 29,175 (7.2) | |
| Unspecific | 1281 (12.1) | 51,508 (12.8) | |
| Grade | < 0.001 | ||
| I | 5582 (52.7) | 74,859 (18.6) | |
| II | 3335 (31.5) | 159,214 (39.5) | |
| III | 389 (3.7) | 150,305 (37.3) | |
| IV | 21 (0.2) | 2554 (0.6) | |
| Unspecific | 1266 (12.0) | 15,865 (3.9) | |
| SEER stage | < 0.001 | ||
| Local | 9134 (86.2) | 252,467 (62.7) | |
| Regional | 1137 (10.7) | 127,795 (31.7) | |
| Distant | 197 (1.9) | 18,965 (4.7) | |
| Unspecific | 125 (1.2) | 3570 (0.9) | |
| T-stage | < 0.001 | ||
| T1 | 6732 (63.5) | 234,608 (58.2) | |
| T2 | 2816 (26.6) | 119,558 (29.7) | |
| T3 | 519 (4.9) | 20,073 (5.0) | |
| T4 | 207 (2.0) | 16,860 (4.2) | |
| Unspecific | 320 (3.0) | 11,698 (2.9) | |
| N-stage | < 0.001 | ||
| N0 | 9058 (85.5) | 255,082 (63.3) | |
| N1 | 822 (7.8) | 93,750 (23.3) | |
| N2 | 143 (1.3) | 22,938 (5.7) | |
| N3 | 99 (0.9) | 15,704 (3.9) | |
| Unspecific | 471 (4.4) | 15,323 (3.8) | |
| M-stage | < 0.001 | ||
| M0 | 10,202 (96.3) | 379,350 (94.2) | |
| M1 | 183 (1.7) | 17,192 (4.3) | |
| Unspecific | 208 (2.0) | 6255 (1.6) | |
| TNM stage | < 0.001 | ||
| I | 6381 (60.2) | 187,086 (46.4) | |
| II | 3183 (30.0) | 139,311 (34.6) | |
| III | 402 (3.8) | 45,608 (11.3) | |
| IV | 183 (1.7) | 17,195 (4.3) | |
| Unspecific | 444 (4.2) | 13,597 (3.4) | |
| ER | < 0.001 | ||
| Negative | 187 (1.8) | 83,543 (20.7) | |
| Positive | 9915 (93.6) | 305,234 (75.8) | |
| Unspecific | 491 (4.6) | 14,020 (3.5) | |
| PR | < 0.001 | ||
| Negative | 1036 (9.8) | 123,454 (30.6) | |
| Positive | 8958 (84.6) | 262,619 (65.2) | |
| Unspecific | 599 (5.7) | 16,724 (4.2) | |
| HER2 | < 0.001 | ||
| Negative | 5124 (48.4) | 182,050 (45.2) | |
| Positive | 286 (2.7) | 40,845 (10.1) | |
| Unspecific | 5183 (48.9) | 179,902 (44.7) | |
| Molecular subtypes | < 0.001 | ||
| Luminal A | 5088 (48.0) | 153,463 (38.1) | |
| Luminal B | 255 (2.4) | 28,240 (7.0) | |
| HER2-enriched | 30 (0.3) | 12,517 (3.1) | |
| Basal subtypes | 29 (0.3) | 28,371 (7.0) | |
| Unspecific | 5191 (49.0) | 180,206 (44.7) | |
| Surgery | < 0.001 | ||
| No | 580 (5.5) | 25,525 (6.3) | |
| Yes | 9952 (93.9) | 373,914 (92.8) | |
| Partial mastectomy | 6713 (63.4) | 222,175 (55.2) | |
| Total mastectomya | 1878 (17.7) | 75,800 (18.8) | |
| Radical mastectomyb | 1334 (12.6) | 74,648 (18.5) | |
| Unknown | 27 (0.3) | 1291 (0.3) | |
| Unspecific | 61 (0.6) | 3358 (0.8) | |
| Radiotherapy | < 0.001 | ||
| No | 5530 (52.2) | 196,512 (48.8) | |
| Yes | 5063 (47.8) | 206,285 (51.2) | |
| Survival | < 0.001 | ||
| 5-year CSS rate | 96.4 | 89.0 | |
| 10-year CSS rate | 93.4 | 83.8 | |
| Early stage 5-year CSS rate | 97.67 | 92.00 | |
| Advanced stage 5-year CSS rate | 38.81 | 27.70 |
aA simple mastectomy removes all breast tissue, the nipple, and areolar complex. An axillary dissection is not done
bRadical mastectomy includes modified radical mastectomy, radical mastectomy NOS and extended radical mastectomy