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. 2021 May 11;19:134. doi: 10.1186/s12951-021-00877-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — a Thermal images of MDA-MB-231-tumor-bearing mice from different treating groups (PBS + laser, Lipo/ICG + laser, and Lipo/pB-DOX/ICG + laser) under 808 nm laser irradiation for different irradiation periods. b Temperature change curves at the tumor sites of different treatment groups during 808 nm laser irradiation. c Tumor volume curves of different groups after various treatments including: PBS, PBS + laser, DOX·HCl, Lipo/pB-DOX, Lipo/ICG + laser, Lipo/pB-DOX/ICG, and Lipo/pB-DOX/ICG + laser. d Photographs of tumor tissues removed from groups treated with different formulations after 21 d. The red circles indicated disappeared tumors. e Tumor weights of each group at the end of experiment and IRT. f Body weight curves of MDA-MB-231 tumor-bearing mice for each group. g Representative histological images of tumor and heart samples from the treated mice. (The data are shown as mean ± SD, n = 5 per group, NS, no significance, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)