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. 2021 Apr 22;22(1):668. doi: 10.3892/etm.2021.10100

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Copyright: © Otaka et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Changes in mRNA expression of encoding genes associated with a pro-inflammatory macrophage phenotype and a reparative macrophage phenotype during hepatotoxicity. mRNA expression of pro-inflammatory macrophage (A) TNFα, (B) IL-1β and (C) IL-6, and markers of reparative macrophages, including (D) Fizz1 and (E) mannose receptor in the livers of mice treated with MCT. Data are expressed as the mean ± SD (n=4-6 mice per group). ^*P<0.05 vs. 0 h. MCT, monocrotaline; TNF, tumor necrosis factor; IL, interleukin; Fizz1, found in inflammatory zone 1; MR, mannose receptor.