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. 2021 Apr 22;22(1):664. doi: 10.3892/etm.2021.10096

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of UA and miR-770-5p inhibitor on apoptosis-related gene expression levels in Min6 cells. Following transfection, Min6 cells were treated with UA (5 mg/dl) for 24 h. (A) Western blotting was performed to measure the protein expression levels of Bax, Bcl-2, cleaved-caspase-3 and caspase-3. (B) The ratio of cleaved-caspase-3/caspase-3. Reverse transcription-quantitative PCR were performed to measure (C) Bax and (D) Bcl-2 mRNA expression levels. ^**P<0.01 vs. control; ^##P<0.01 vs. UA; ^&&P<0.01 vs. inhibitor. UA, uric acid; miR, microRNA; siRNA, small interfering RNA.