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. 2021 Apr 6;44(4):267–278. doi: 10.14348/molcells.2021.2179

Fig. 6. Ectopic expression of MT1M inhibits SOD1/PI3K signaling pathway.

Fig. 6

(A) SOD1 is a directly interacting gene of MT1M. MT1M expression is inversely correlated with SOD1 level (https://string-db.org/). (B) Expression levels of SOD1, SOD2, SOD3, Nrf2, GPx2, phosphorylation of SOD1 downstream targets PI3K, Akt, ERK were lowered by western blot in vector and MT1M expressing cells. (C) MT1M suppressed SOD1 activity (*P < 0.05). (D) MT1M evaluated intracellular ROS level (*P < 0.05). (E) Quantitative analysis of western blots (*P < 0.05, **P < 0.01).