Fig. 4.

Subsets of immune network alterations in brain vasculome. (A) Altered immune pathways comprise cytokine-cytokine receptor interactions, Toll-like signaling, complement cascades, and Fc gamma receptor signaling. Note that in spite of the overall suppression of immune function, the responses to aging, hypertension and diabetes were mostly unique and showed very little common genes (gray indicates genes affected in all 3 conditions). (B) Quantitative z-scores of specific pathway downregulation.