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. 2021 Apr 27;11:637826. doi: 10.3389/fendo.2020.637826

Figure 1.

Figure 1

Representation of immune cells, solule mediators, and negative immune checkpoints in tumor microenvironment (TME) of thyroid tumor histotypes based on the studies carried out so far. TME of DTCs is the most frequently studied also because they are the most common thyroid carcinomas. ATCs have been shown to be richly infiltrated by cells and mediators of immune system. The few works on PDTCs display TAMs and TAMCs in their TME (see text for details).: DTC, differentiated thyroid cancer; ATC, anaplastic thyroid cancer; PDTC, poorly differentiated thyroid cancer; NK, natural killer; TAM, tumor-associated macrophage; TAN, tumor-associated neutrophil; TAMC, tumor-associated mast cell; CTL, cytotoxic T lymphocyte; DC, dendritic cell; CD4+T, CD4+ T helper cell; MDSC, myeloid-derived suppressor cell; CXCL, C-X-C motif chemokine ligand; CCL, C-C motif chemokine ligand; TGF-β, transforming growth factor-β; IDO1, indoleamine 2,3-dioxygenase 1; ARG, arginase; CTLA-4, cytotoxic T-lymphocyte associated protein 4; TIM3, T cell immunoglobulin and mucin domain 3; LAG3, lymphocyte activation gene 3; PD-L1, programmed cell death ligand 1.