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. 2021 Apr 13;11:614024. doi: 10.3389/fphar.2020.614024

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Copyright © 2021 Wang, Peng, An, Shang, Xiao, He, Chen, Zhang, Wang, Wang, Zhang, Gao, Zhu and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XBJ and C0127s intervention protected hearts in septic mice. (A) N-terminal (NT)-pro hormone BNP (NT-ProBNP) levels in different groups were determined by Elisa assay. n = 4/group. mRNA expression of B-type natriuretic peptide (BNP) (B), TLR4 (C), HMGB1(D), Periostin (E), and GRP78 (F) in heart tissue of different groups were determined by real-time PCR in heart tissue of different groups. n = 4–5/group. Results were presented as mean ± SEM (n = 4-5/group). ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs. Sham group, *p < 0.05, **p < 0.01, ***p < 0.001 vs. CLP group.