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. 2021 Apr 13;11:614024. doi: 10.3389/fphar.2020.614024

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Copyright © 2021 Wang, Peng, An, Shang, Xiao, He, Chen, Zhang, Wang, Wang, Zhang, Gao, Zhu and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XBJ and C0127s down-regulated TNF-α signaling in the cardiac tissue of septic mice on mRNA level. (A) Heat map of the gene expression influenced by XBJ and C0127s in TNF-α signaling in the RNA-seq assay. (B–E) Real-time PCR experiments were conducted to confirm the results of RNA-seq assay. B. Birc3; C. C/EBPβ; D. FOS; E. CXCL5. n = 4/group. All Real-time PCR experiments were conducted twice. Results were presented as mean ± SEM (n = 4/group). #p < 0.05, ##p < 0.01, ###p < 0.001 vs. Sham group, *p < 0.05, **p < 0.01, ***p < 0.001 vs. CLP group.