Table 1.
Imprinted gene candidates for conferring susceptibility to type 2 diabetes.
| Study | Imprinted loci or gene affected | Methods used | Human population(s) |
|---|---|---|---|
| (115) | 11p15 and 7q32 | GWAS - SNP chips (T2D vs control) | Icelandic |
| (116) | KCNQ1 | GWAS - SNP genotyping (T2D vs control) | Japanese, Korean, Chinese and European |
| (117) | KCNQ1 | GWAS - SNP genotyping (T2D vs control) | Japanese, Singaporean and Danish |
| (118) | GRB10 | GWAS - SNP array (T2D vs control) | Amish and Scandinavian |
| (107) | GRB10 | Meta-analysis of multiple GWAS (based on reduced GSIS) and SNP arrays | Multiple backgrounds |
| (86) | MEG3 | Micro RNA sequencing in dispersed/FACS-sorted human islets (T2D vs control) | Multiple backgrounds |
| (113) | DLK1 and PLAGL1 | Single cell transcriptomics in dispersed human islets (T2D vs control) | Multiple backgrounds |
| (112) | PEG3 | RNA and exome sequencing in whole human islets (T2D vs control) | European |
| (111) | KCNQ1 | Genome-wide DNA methylation and transcriptomic analysis in dispersed/FACS-sorted human islets (T2D vs control) | Swedish |
| (114) | GRB10 | Genome-wide DNA methylation and transcriptomic analysis with SNP array in isolated human islets from non-diabetic donors | Swedish |
This has been assessed using GWAS and SNP analysis or via differential expression and/or methylation of imprinted genes in isolated islets from T2D vs control subjects.