Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 14;12:633821. doi: 10.3389/fphar.2021.633821

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Chasset, Dayer and Chizzolini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic model of the cascade of events characterizing the IFN response in SADs. Blue: antigen drive; gradient blue: facilitator mechanisms for antigen uptake; yellow: receptors; green: intracellular signaling; red: IFN and ISG. The arrows indicate feed-forward regulatory mechanisms. Orange ovals: main cells implicated in IFN-I production. Abbreviations: IC: immune complexes; IFNAR: interferon-alpha/beta receptor; ISG: interferon-stimulated gene; ISRE: IRF: interferon regulatory factor; JAK: Janus kinase; LDG: low-density granulocyte; LL-37: cathelicidin-37; pDC: plasmacytoid dendritic cell; PMN: polymorphonuclear neutrophil; PRR: pattern recognition receptor; SADs: systemic autoimmune diseases; STAT: signal transducer and activator of transcription.