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Receptors and main signaling molecules used by IFNs.
| IFN-I | IFN-II | IFN-III | |
|---|---|---|---|
| Receptor subunits | IFNAR1 | IFNGR1 | IFNLR1 |
| IFNAR2 | IFNGR2 | IL-10R2 | |
| Receptor expression | All nucleated cells | All nucleated cells | Epithelial cell pDCs |
| Signaling molecules | JAK1 and TYK2 | JAK1 and JAK2 | JAK1 and TYK2 |
| Transcription factors | STAT1/STAT2/IRF9 | STAT1/STAT1 | STAT1/STAT2/IRF9 |
| STAT1/STAT1 | STAT1/STAT1 |
