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. 2021 Apr 14;12:632028. doi: 10.3389/fphar.2021.632028

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Copyright © 2021 Renno, Afzal, Paul, Nair, Kumar and Al-Hassan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Toluidine blue-stained photomicrographs of semi-thin transverse sections of sciatic nerves obtained from animals in the SHAM (A–C), CRUSH (D–F), CRUSH + 0.5X SPF-FB(IP) (G–I) and CRUSH + 1X SPF-FB(S.C.) (J–L) groups at week 6 following nerve injury (Column I; ×100, Column II, ×400 and Column III, ×1,000). Although sciatic nerves from CRUSH (D–F) animals display regenerative recovery but still show the presence of smaller mini-fascicles nerve fibers with thin myelin sheaths and more myelin configurations and debris (arrows) at week 6 following crush injury, in contrast, sciatic nerve sections of and CRUSH + 0.5X SPF-FB(IP) (G–I) and CRUSH + 1X SPF-FB (S.C.) (J–L) groups show remarkable nerve regeneration with less myelin debris compared to those from the CRUSH (D–F) group. Note that the SPF-FB-treated nerves show more compactly arranged, regularly shaped, and more myelin surrounding the axons compared to the CRUSH group.