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. 2021 Apr 14;12:632028. doi: 10.3389/fphar.2021.632028

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Copyright © 2021 Renno, Afzal, Paul, Nair, Kumar and Al-Hassan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Photomicrographs of lumbar spinal cord (A): ventral and (B): dorsal grey horns from rats of all groups stained with Cresyl violet stain at Week 4 and Week 6 following sciatic nerve injury (100×). The degenerating neurons have prominent shrunken eosinophilic cytoplasm and are primarily characterized by nuclear pyknosis (either pyknotic or karyorrhectic nuclei). It is this heterogeneous appearance that typifies neuronal degeneration. Note fewer neurons and degenerating neurons (arrows) with less Nissl substance that appear pale because of the dissociation of ribosomes from the rough endoplasmic reticulum in the nerve-injured CRUSH than the SHAM group. The number of normally looking neurons is remarkably more in CRUSHvSPF-FB(IP) and CRUSH + SPF-FB(S.C.)-treated groups than the CRUSH group.