Fig. 1. Effect of co-administration of probiotics and prebiotics on the number of fecal pellets (A), weight of fecal pellets (B), and fecal water content (C) in loperamide-induced constipated rats.

Data are expressed as mean±SEM for each group, and different symbols indicate significant differences. ^* p<0.05 and ^** p<0.01 vs. Lop group. Cont, control group; Lop, loperamide-induced group; Lop-Pro, loperamide-induced group with multi-strain probiotics group (LACTO 5X); Lop-Pro/Pre, loperamide-induced group with multi-strain probiotics and prebiotics mixture (LACTO 5X synbiotic) group.