Table 2.
Site | Reason |
---|---|
Oral cavity, esophagus | Invasion assessment of a scant focus (2) |
Lung | Unusual morphology of metastasis in a known case |
Oral cavity, cervix | Grading of dysplasia (2) |
Mediastinum | Grey zone between Hodgkin lymphoma and primary mediastinal B-cell lymphoma |
Hard palate, urinary bladder, lung | Grading of tumor (3) |
Ascitic fluid | Scant atypical cells (3) |
Gallbladder | Scant focus of adenocarcinoma |
Colorectum, lung, nasal cavity | Poorly differentiated malignant tumor (3) |
Colorectum | Inflammatory atypia versus dysplasia |
Ascitic fluid | Presence of nucleated RBCs |
Liver biopsy | Carcinoma inconclusive on IHC |
Breast | Fixation artifacts |
Breast | IHC internal control unsatisfactory (2) |
Breast, lung | Pixelation and WSI latency (2) |
Lung | Neoplastic versus reactive spindle cell proliferation |
Lung | Benign versus low-grade neoplasm |
Endometrium | Proliferative changes versus hyperplasia |
*Numbers in brackets indicate number of cases with the same reason for deferral. ESI: Whole-slide imaging, IHC: Immunohistochemistry, RBCs: Red blood cells, WSI: Whole-slide imaging