Table 6.

Discordances between whole-slide imaging and glass reads

	Site/diagnosis	WSI	Glass	Reference	Discordance
1	High-grade urothelial carcinoma of urinary bladder	Lamina propria invasion is not seen	Focal lamina propria invasion is seen	Lamina propria invasion is seen	Minor
2	Invasive breast carcinoma	HER2/neu equivocal (score 2+) by IHC	HER2/neu negative (score 1+) by IHC	HER2/neu negative (score 1+) by IHC	Minor
3	Breast	Invasive breast carcinoma Grade 2. Modified RB score 3+2=2=7	Invasive breast carcinoma Grade 3. Modified RB score 3+3+2=8	Invasive breast carcinoma Grade 3. Modified RB score 3+3+2=8	Minor
4	Lung	Adenocarcinoma	Adenosquamous carcinoma	Adenosquamous carcinoma	Minor
5	Oral cavity	Atypical squamous proliferation, suspicious for squamous cell carcinoma	Squamous cell carcinoma	Squamous cell carcinoma	Minor
6	Oral cavity	Atypical squamous proliferation, suspicious for squamous cell carcinoma	Squamous cell carcinoma	Squamous cell carcinoma	Minor
7	Oral cavity	Atypical squamous proliferation, suspicious for squamous cell carcinoma	Consistent with squamous cell carcinoma	Squamous cell carcinoma	Minor

WSI: Whole-slide imaging, IHC: Immunohistochemistry, HER2: Human epidermal growth factor receptor 2, RB: Richardson-Bloom