Table 5.

Clinically significant discrepancies in gastrointestinal tract

Sub speciality	Glass diagnosis	Digital diagnosis	3rd pathologist/multi header review diagnosis	Ground truth	Number of repeats
GIT	Hyperplastic polyp	Tubular adenoma with low grade dysplasia	Hyperplastic polyp	GS	Overcall of dysplasia on DP, ×6
GIT	Barrett’s oesophagus with low grade dysplasia	Barrett’s oesophagus No dysplasia seen	Barrett’s oesophagus with low grade dysplasia	GS	Undercall of dysplasia on DP, ×4
GIT	TVA with high grade dysplasia	Moderately differentiated invasive adenocarcinoma in a TVA with high grade dysplasia	Moderately differentiated invasive adenocarcinoma in a TVA with high grade dysplasia	DP	None
GIT	Hyperplastic polyp	Sessile serrated adenoma with low grade dysplasia	Hyperplastic polyp	GS	×2
GIT	Normal large bowel mucosa	Large bowel mucosa with features of lymphocytic colitis	Normal large bowel mucosa	GS	None
GIT	Duodenal mucosa with features of early coeliac disease	Normal duodenal mucosa	Duodenal mucosa with features of early Coeliac disease	GS	None
GIT	Nonspecific chronic gastritis	H. pylori active chronic gastritis	H. pylori active chronic gastritis	DP	×2
GIT	Nonspecific chronic gastritis	H. pylori associated chronic gastritis	Nonspecific chronic gastritis	GS	×2
GIT	H. pylori associated chronic gastritis	Gastric mucosa suggestive of marginal zone lymphoma of MALT type	Gastric mucosa suggestive of marginal zone lymphoma of MALT type	DP	None
GIT	Normal small bowel mucosa	Sections of irritated seborrhoiec keratosis	Pathologist reporting DP wrongly entered a different report on data sheet	QC issues	Misidentifi-cation error, ×1

H. pylori: Helicobacter pylori, TVA: Tubulo villous adenoma, DP: Digital pathology, GIT: Gastrointestinal tract, GS: Glass slide, MALT: Mucosaassociated lymphoid tissue