Table 2.
Serum autoimmune encephalopathy panel (performed by Mayo Clinic Laboratories)
| Result name | Result | Reference value |
| Glutamic acid decarboxylase 65 antibody | 0.28 nmol/L | ≤0.02 |
| Acetylcholine receptor Ganglionic Neuronal Ab | 0.00 nmol/L | ≤0.02 |
| AMPA-R Ab CBA | Negative | Negative |
| Amphiphysin Ab | Negative | <1:240 |
| AGNA-1 | Negative | <1:240 |
| ANNA-1 | Negative | <1:240 |
| ANNA-2 | Negative | <1:240 |
| ANNA-3 | Negative | <1:240 |
| CASPR2-IgG CBA | Negative | Negative |
| CRMP-5-IgG | Negative | <1:240 |
| DPPX Ab IFA | Negative | Negative |
| GABA-B-R Ab CBA | Negative | Negative |
| GFAP IFA | Negative | Negative |
| IgLON5 IFA | Negative | Negative |
| LGI1-IgG CBA | Negative | Negative |
| mGluR1 Ab IFA | Negative | Negative |
| NIF IFA | Negative | Negative |
| NMDA-R Ab CBA | Negative | Negative |
| N-type calcium channel Ab | 0.00 nmol/L | ≤0.03 |
| P/Q-type calcium channel Ab | 0.00 nmol/L | ≤0.02 |
| Purkinje cell cytoplasmic Ab type 1 | Negative | <1:240 |
| Purkinje cell cytoplasmic Ab type 2 | Negative | <1:240 |
| Purkinje cell cytoplasmic Ab type Tr | Negative | <1:240 |
GAD65 Ab is consistent with predisposition to thyrogastric disorders, including thyroiditis, pernicious anaemia and type 1 diabetes, but has low specificity for autoimmune encephalopathy. GAD65 antibody values less than 2.00 nM have a lower positive predictive value for neurological autoimmunity than values of 20.0 nM and higher.
Ab, antibody; AGNA, antiglial nuclear antibody; AMPA-R Ab CBA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody cell-binding assay; ANNA, anti-neuronal nuclear antibody; CASPR2-IgG CBA, contactin-associated protein 2-immunoglobulin G cell-binding assay; CRMP-5-IgG, collapsin response-mediator protein-5- Immunoglobulin G; DPPX Ab IFA, dipeptidyl peptidase-like protein 6 antibody indirect fluorescent antibody; GABA-B-R Ab CBA, gamma-aminobutyric acid-B-receptor Antibody cell-binding assay; GFAP IFA, glial fibrillary acidic protein indirect fluorescent antibody; IgLON5 IFA, immunoglobulin-like cell adhesion molecule 5 Indirect fluorescent antibody; LGI1-IgG CBA, leucine rich glioma Inactivated 1- immunoglobulin G cell-binding assay; mGluR1 Ab IFA, metabotropic glutamate receptor 1 antibody indirect fluorescent antibody; NIF IFA, neuronal intermediate filament indirect fluorescent antibody; NMDA-R Ab CBA, N-methyl-D-aspartate receptor antibody cell-binding assay.