Table 2.
TRP–host protein interactions to influence cell signaling.
| Host protein | Function | ||
|---|---|---|---|
| TRP | Symbol | Full name | Cell signaling |
| TRP32 | CD14 | CD14 molecule | MAPK, TLR, IKK/NFκB and LPS |
| CD63 | CD63 molecule | Integrin and VEGF | |
| IGHA1 | Immunoglobulin heavy constant alpha 1 | B cell receptor | |
| IGHV | Immunoglobulin heavy chain variable region | Notch and B cell receptor | |
| IGHLL5 | Immunoglobulin lambda like polypeptide 5 | B cell receptor | |
| RC3H1 | Ring finger and CCCH-type domain 1 | T cell receptor and NFκB | |
| TRP47 | BPI | Bactericidal/permeability-increasing protein | IL, TNF and TLR |
| CAB39 | Calcium binding protein 39 | PI3K/Akt/mTOR and IGF1R, | |
| CDK1 | Cyclin dependent kinase 1 | p53, MAPK and Hedgehog | |
| CDK10 | Cyclin dependent kinase 10 | MAPK | |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | Fcγ receptor, T cell receptor, MAPK, IKK/NFκB, PI3 and C-type lectin receptor | |
| GNB1 | G protein subunit beta 1 | GPCR, Ras, Wnt, PI3K/Akt, Hedgehog, CXCR3/4 and cytokine | |
| IGLL1 | Immunoglobulin lambda like polypeptide 1 | B cell receptor | |
| PRTN3 | Proteinase 3 | Cytokine and IL | |
| PTPN2 | Protein tyrosine phosphatase, non-receptor type 2 | ERK1/2, EGF receptor, IFNγ, IL, TNF, IFN and T cell receptor | |
| TRP75 | ANXA5 | Annexin A5 | NFκB, PI3K/Akt/mTOR, ERK and p38 MAPK |
| CD84 | Cluster of differentiation 84 | Cell survival | |
| CSF1 | Colony stimulating factor 1 | PI3K/AKT/mTOR | |
| IFNLR1 | Interferon lambda receptor 1 | Cytokine ligands IFNL2 and IFNL3 receptor | |
| ITGB1 | Integrin beta-1 | Collagen receptor | |
| ITGB2 | Integrin beta-2 | ICAMs and ubiquitin-like proteins receptor | |
| MMP9 | Matrix metalloproteinase-9 | Cytokine-mediated signaling and peptidase activity | |
| NPTN | Neuroplastin | FGFR1 signaling | |
| PI4KA | Phosphatidylinositol 4-kinase alpha | Signal transduction | |
| PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Catalytic subunit of AMP-activated protein kinase (AMPK) | |
| RAB3GAP1 | Rab3 GTPase-activating protein catalytic subunit | GTPase activity | |
| RAD50 | DNA repair protein RAD50 | Cellular response to DNA damage | |
| RB1CC1 | RB1-inducible coiled-coil protein 1 | Autophagy | |
| SEPW1 | Selenoprotein W | Glutathione (GSH)-dependent antioxidant | |
| SGSM3 | Small G protein signaling modulator 3 | GTPase activity | |
| SH3BP5 | SH3 domain-binding protein 5 | BTK-related cytoplasmic signaling in B-cells | |
| SPP1 | Secreted Phosphoprotein 1 | Hedgehog, PTH and Integrin | |
| TRP120 | ADAM17 | ADAM metallopeptidase domain 17 | Hedgehog, EGFR, TGFβ, GPCR, Notch, TNF and cytokine/chemokine |
| AKAP2 | A kinase anchor protein 2 | GPCR | |
| ANXA2 | Annexin A2 | NFκB, IL, EGFR, STAT3, Calcium and Wnt | |
| CXCL12 | C-X-C motif chemokine ligand 12 | NFκB, GPCR and chemokine | |
| GCSAM | Germinal center associated signaling and motility | B cell receptor | |
| GNAI2 | G protein subunit alpha i2 | MAPK, GPCR and chemokine | |
| GPS1 | G protein pathway suppressor 1 | MAPK, JNK and GPCR | |
| IFNGR2 | Interferon gamma receptor 2 | JAK-STAT and IFNγ | |
| IL2RG | Interleukin 2 receptor subunit gamma | MAPK, PI3K/Akt, IL and FGFR | |
| KRAS | KRAS proto-oncogene, GTPase | MAPK, NFκB, EGFR, Ras and Rac | |
| LGALS1 | Galectin 1 | IKK/NFκB | |
| PDE1B | Phosphodiesterase 1B | GPCR, PLC, EGFR and FGFR | |
| PPP3R1 | Protein phosphatase 3 regulatory subunit B, alpha | Wnt, MAPK | |
| TLE4 | Transducin like enhancer of split 4 | Wnt, Notch | |
| TRP120/TRP32 | IGHA1 | Immunoglobulin heavy constant alpha 1 | B cell receptor |
| IGLL5 | Immunoglobulin lambda like polypeptide 5 | B cell receptor | |
| TRP120/TRP47 | IGKC | Immunoglobulin kappa constant | B cell receptor signaling pathway |