Figure 7.

Comparison of CD159a and KIR receptors mean fluorescence intensities (MFI) of different NK maturation subsets within the bone marrow microenvironment of NBM, MDS, and AML cases. (A–D) Left panel: CD56^bright CD94^hi CD16^- CD57^- immature NK subset; middle panel: CD56^dim CD94^med CD16⁺ CD57^- mature NK subset; right panel: CD56^dim CD94^low CD16⁺ CD57⁺ hypermature NK subset; (A) CD159a MFI of different bone marrow NK maturation subsets in normal bone marrow (NBM, n = 30), myelodysplastic syndromes (MDS, n = 25), and acute myeloid leukemias (AML, n = 8) cases. Bars represent the mean ± SEM (*P < 0.05, ns, not significant; one-tailed unpaired t-test, and Mann Whitney test only for comparing the MFI means of mature NK subsets of NBM vs. MDS: Mann Whitney test). (B) CD158a MFI, (C) CD158b MFI, (D) CD158e1 MFI of different bone marrow NK maturation subsets in NBM (n = 30), MDS (n = 24), and AML (n = 8) cases. Bars represent the mean ± SEM (*P < 0.05, ns, not significant; one-way ANOVA followed by Tukey’s Multiple Comparison test).