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. 2021 Apr 27;12:665541. doi: 10.3389/fimmu.2021.665541

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Copyright © 2021 Cianga, Campos Catafal, Cianga, Pavel Tanasa, Cherry, Collet, Tavernier, Guyotat, Rusu and Aanei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences in the repartition of CD159a and KIR receptors in distinct NK maturation subsets within the bone marrow microenvironment of NBM, MDS, and AML cases. (A) Mean fluorescence intensity (MFI) of CD159a and KIR receptors on the surface of bone marrow CD56^bright CD94^hi CD16^- CD57^- immature NK cells in normal bone marrow (NBM, n = 30), myelodysplastic syndromes (MDS, n = 25), and acute myeloid leukemia (AML, n = 8) cases. Bars represent the mean ± SEM (*P < 0.05; two-way ANOVA followed by Bonferroni post-test). (B) Mean fluorescence intensity (MFI) of CD159a and KIR receptors on the surface of marrow CD56^dim CD94^med CD16⁺ CD57^- mature NK cells in NBM (n = 30), MDS (n = 25), and AML (n = 8) cases. Bars represent the mean ± SEM (ns, not significant; two-way ANOVA followed by Bonferroni post-test). (C) Mean fluorescence intensity (MFI) of CD159a and KIR receptors on the surface of bone marrow CD56^dim CD94^low CD16⁺ CD57⁺ hypermature NK cells in NBM (n = 30), MDS (n = 25), and AML (n = 8) cases. Bars represent the mean ± SEM (*P < 0.05; two-way ANOVA followed by Bonferroni post-test).