Table 1.
Relationships of Liver, Metabolic, and Inflammatory Indices with Interleukin-18 and Monocyte Chemoattractant Protein-1 in People with HIV
| Log10 (IL-18) |
Log10 (MCP-1) |
|||
|---|---|---|---|---|
| r | p | r | p | |
| Liver | ||||
| Log10 (AST) | 0.34 | .0001 | 0.27 | .004 |
| Log10 (ALT) | 0.33 | .0002 | 0.26 | .006 |
| Liver/spleen ratio | −0.24 | .02 | −0.20 | .06 |
| Glucose | ||||
| Fasting glucose | 0.08 | .40 | 0.09 | .33 |
| Log10 (hemoglobin A1c) | −0.09 | .32 | −0.001 | .99 |
| Lipids | ||||
| Total cholesterol | −0.02 | .83 | −0.06 | .52 |
| LDL | −0.01 | .87 | −0.05 | .63 |
| HDL | −0.28 | .002 | −0.25 | .009 |
| Log10 (triglycerides) | 0.26 | .003 | 0.25 | .007 |
| Fat distribution | ||||
| BMI | −0.04 | .64 | 0.06 | .53 |
| Log10 (VAT) | 0.12 | .19 | 0.22 | .02 |
| Log10 (SAT) | −0.15 | .09 | −0.004 | .97 |
| Inflammatory markers | ||||
| Log10 (MCP-1) | 0.33 | .0004 | — | — |
| Log10 (IL-18) | — | — | 0.33 | .0004 |
| Log10 (LPS) | 0.28 | .004 | 0.02 | .86 |
| Log10 (caspase-1) | 0.35 | <.0001 | 0.15 | .13 |
| HIV disease parameters | ||||
| Log10 (viral load) | 0.29 | .002 | −0.03 | .74 |
| Log10 (CD4+ T cell count) | −0.17 | .06 | 0.12 | .21 |
| Log10 (CD8+ T cell count) | 0.13 | .16 | 0.24 | .01 |
| Log10 (CD4+/CD8+ ratio) | −0.24 | .007 | −0.05 | .61 |
| Adjusted relationships with log10 (IL-18) | β | p | ||
| Log10 (AST)a | 0.31 | .004 | ||
| Log10 (ALT)a | 0.43 | .003 | ||
| Liver-to-spleen ratiob | 0.63 | .02 | ||
Bold values denote statistical significance at p-value < 0.05.
a
Multivariate analysis adjusting for age, gender, BMI, log10 triglycerides, statin use, log10 HIV RNA, and log10 CD4 count.
b
Multivariate analysis adjusting for age, gender, BMI, log10 triglycerides, fasting glucose, and log10 VAT area.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HDL, high-density lipoprotein; IL, interleukin; LDL, low-density lipoprotein; MCP-1, monocyte chemoattractant protein-1; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.