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. Author manuscript; available in PMC: 2021 May 11.
Published in final edited form as: Nature. 2019 Dec 18;577(7789):249–253. doi: 10.1038/s41586-019-1843-6

Extended Data Figure 9. IL-17a is necessary for LPS-induced behavioral rescue and reduction of c-Fos expression in MIA offspring.

Extended Data Figure 9.

a-e, Further behavioral analyses of experiments described in Fig. 4a; Time spent investigating social (S) versus inanimate (I) objects (b), total interaction time (c), time spent in social (S), center (C) or inanimate (I) chamber (d), and distance traveled (e) (PBS-Veh-Isotype n=9, PBS-LPS-Isotype n=11, MIA-Veh-Isotype n=10, MIA-LPS-Isotype n=10, MIA-LPS-αIL-17a n=10; from 7 independent experiments). f, Quantification of c-Fos expressing cells in the S1DZ and CeA following Veh or LPS injection in MIA offspring pretreated i.c.v. with isotype control antibody or blocking antibody against IL-17a (αIL-17a). Statistics calculated by two-way ANOVA with Sidak’s (b) and Dunnett’s (d) post-hoc tests, two-way repeated measures ANOVA with Sidak’s post-hoc tests (c,e), and one-way ANOVA with Dunnett’s post-hoc test (f). Graphs indicate mean ± s.e.m.