Table 1.
Selected examples of nanoparticles used in fluorescence biomedical applications
| Author | NP type | Imaging agent | Size (nm) | Applications | Experimental model | Ref |
|---|---|---|---|---|---|---|
| Grebenik E,A | PMAO-(β-NaY0.78Yb0.2Er0.02F4)-Bs:Bn-scFc4D5 | UCNP | 120 | Detecting early stage breast cancer | SK-BR-3 human cancer cells, CHO-K1 Chinese hamster ovary cells | 61 |
| Lee S | Cy5.5-substrate/AuNP | Cy5.5 | 20 | Detecting protease activity | Mice bearing SCC7 tumors | 67 |
| Sun I,C | Cy5.5-DEVD-DOPAK/AuNP | Cy5.5 | 37.8 | Testing caspase-3 to identify apoptosis activity in cells | HeLa cells | 68 |
| Chen L,J | PLNP(Zn1.1Ga1.8Ge0.1O4:Cr3+)-CuS-RGD | PLNP | 141 | Detecting tumor and guiding therapy | SCC-7 cells, 293T cells and athymic BALB/c nude mice bearing SCC-7 cells | 69 |
| Li L | DNAzymes(Zn-Enz)/AuNP-FAM/BHQ-1, DNAzymes(Cu-Enz)/AuNP-Cy5/BHQ-2 | FAM,Cy5 | 13 | Tracking ion of Zn and Cu in alive cell | HepG2 cells | 70 |
| Muthukumar T | CNP(Mtx-Asp-FITC) | FITC | 90.9 | Monitoring therapeutic drug delivery | A549 lung cancer cells | 78 |
| Markovic S | Cy7.5-INCeRT | Cy7.5 | 30, 200 | Monitoring drug diffusion | Athymic nude mice | 80 |
| Zhao Y,M | QD710-Cy7-PEGylated lipids | Cy7 | 20 | Monitoring NP accumulation and dissociation kinetics in tumor | Swiss nude mice bearing HCT-116 cells | 85 |
| Gao J,H | QD710-Dendron/RGD (InP/ZnS core/shell QDs) | Quantum dots | 12 | Targeted imaging tumor cells | BALB/c mice, athymic nude mice bearing SKOV3 tumors | 87 |
| Geng J,L | PFVBT(AuNP-PLGA)/(PLGA-PEG2000-folate) | PFVBT | 120 | Detecting MCF-7 cell in breast cancer | Breast cancer cells (MCF-7) | 94 |
| Pu K,Y | Cationic oligofluorene substrated POSS | Ethidium bromide | 3.6 | Imaging double-stranded DNA | Breast cancer cells (MCF-7) | 101 |
| Blechinger J | Perylenediimide-containing polysiloxane core and silica shell | Perylenediimide | 18, 70 | Detecting nanotoxicity in alive cells | HeLa cells | 102 |
| Chen G,J | AB3-UCNP(NaYF4:Yb/Tm/Er)-RB/KE108 | UCNP | 14 | Monitoring cellular uptake of nanoparticles and combined with therapy | TT cells (human thyroid cancer cells), athymic nude mice bearing TT cells | 103 |
| Iacono P | Au@IR-pHPMA | IR | 55 | Detecting lymph node | Nude mice | 104 |