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. Author manuscript; available in PMC: 2021 May 11.
Published in final edited form as: Trends Biochem Sci. 2020 Nov 30;46(3):225–238. doi: 10.1016/j.tibs.2020.10.006

Figure 6.

Figure 6.

Prp43 in the Spliceosome ILS Complex.

(A) Overall structure of the yeast ILS complex (PDB ID 5Y88). The light blue oval represents the likely location of the Ntr1 G-patch with insufficient density for modeling. (B) A zoomed in view of the Prp43-containing region of the ILS complex. Dotted lines indicate the distance from the U6 small nuclear RNA (snRNA) and the pre-mRNA to the Prp43 RNA-binding groove. (C) A model of how Prp43 translocation along the U6 snRNA could lead to spliceosome disassembly (adapted from [79]). Abbreviations: ILS, intron lariat spliceosome; NTC, NineTeen complex; NTR, NTC related.