Table 3.
The analysis of prognosis factors in 336 gastric cancer patients with MGC component by univariate and multivariate.
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| 5-YSR (%) | P value | HR (95% CI) | P value | ||
| Sex | Male | 42.2 | 0.161 | — | — |
| Female | 51.5 | ||||
| Age (years) | <59 | 54.4 | 0.001 | 1.876 (1.361-2.585) | <0.001∗ |
| ≥59 | 36.4 | ||||
| R0/R1&2 resection | R0 | 51.1 | <0.001 | 1.384 (0.927-2.067) | 0.112 |
| R1/R2 | 14.3 | ||||
| Tumor size (cm) | <5.25 | 59.9 | <0.001 | 0.884 (0.608-1.286) | 0.520 |
| ≥5.25 | 32.6 | ||||
| pMGC/mMGC | mMGC | 47.4 | 0.211 | — | — |
| pMGC | 39.8 | ||||
| Chemotherapy | Yes | 47.1 | 0.191 | — | — |
| No | 43.1 | ||||
| T-stage | T1 | 88.9 | <0.001 | 1.289 (0.948-1.753) | 0.106 |
| T2 | 78.4 | ||||
| T3 | 48.8 | ||||
| T4 | 35.7 | ||||
| N-stage | N0 | 80.6 | <0.001 | 1.136 (0.962-1.341) | 0.132 |
| N1 | 49.2 | ||||
| N2 | 40.3 | ||||
| N3a | 29.5 | ||||
| N3b | 17.4 | ||||
| TNM | I+II | 78.4 | <0.001 | 2.350 (1.216-4.542) | 0.011∗ |
| III | 30.3 | ||||
| Tumor location | L | 54.4 | <0.001 | 1.103 (0.982-1.238) | 0.097 |
| M | 38.3 | ||||
| U | 28.6 | ||||
| LM | 34.2 | ||||
| MU | 18.2 | ||||
| LMU | 20.0 | ||||
| Leukocyte | <6.17 | 49.2 | 0.077 | — | — |
| ≥6.17 | 39.7 | ||||
| Neutrophil | <3.31 | 50.6 | 0.030 | 1.174 (0.818-1.684) | 0.384 |
| ≥3.31 | 40.1 | ||||
| Hemoglobin | <125.1 | 36.9 | 0.009 | 1.096 (0.785-1.528) | 0.591 |
| ≥125.1 | 51.3 | ||||
| Fibrinogen | <3.31 | 52.6 | 0.005 | 0.897 (0.655-1.230) | 0.500 |
| ≥3.31 | 36.8 | ||||
| Albumin | <40.1 | 35.1 | <0.001 | 0.761 (0.553-1.046) | 0.092∗ |
| ≥40.1 | 53.0 | ||||
| Globulin | <29.2 | 48.0 | 0.039 | 1.520 (1.067-2.165) | 0.020∗ |
| ≥29.2 | 35.4 | ||||
| NLR | <1.6 | 55.8 | 0.002 | 1.012 (0.662-1.548) | 0.956 |
| ≥1.6 | 39.5 | ||||
| Platelet | <243 | 51.8 | 0.010 | 0.895 (0.619-1.293) | 0.554 |
| ≥243 | 38.0 | ||||
| PLR | <133 | 55.6 | <0.001 | 1.582 (1.066-2.348) | 0.023∗ |
| ≥133 | 34.5 | ||||
| Total gastrectomy | Yes | 21.7 | <0.001 | 0.537 (0.373-0.772) | 0.001∗ |
| No | 53.7 | ||||
∗ P < 0.05; 5-YSR = 5-year survival rate; L = lower; M = middle; U = upper; NLR = neutrophil-to-lymphocyte ratio; PLR = platelet-to-lymphocyte ratio; MGC = mucinous gastric carcinoma.