Figure 7.

The beneficial effects of oral supplementation of KA from marine horseshoe crab on HFD mice. This study isolated KA from horseshoe crab in for the first time in the world. We found that KA (5 mg/kg/day) inhibited both the body weight gain and the increase of average daily energy intake in HFD mice. We suspect that the improvement effects of KA on HFD-induced obesity and hyperlipidemia may be through the modulation of gut microbiota. Our findings demonstrate the potential therapeutic effects of KA for HFD mice, which were similar to that of simvastatin (positive control). The in vitro results suggest that the improvement effects of KA on HFD mice may be partially associated with antioxidant activity of KA.