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. 2021 Apr 20;42:101959. doi: 10.1016/j.redox.2021.101959

Table 2.

Additional human Prdx structures.

Name PDB Code Redox State Description Oligomeric State Reference
Prdx1 2RII SS CP in disulfide with sulfiredoxin hetero tetramer [72]
Prdx1
C52D/A86E 		3HY2 SS-like In complex with sulfiredoxin (C99A) and ATP:Mg2+; active site similar to SS despite CP mutation hetero tetramer [73]
Prdx1 C83S 4XCS SS Oxidation/disulfide formation of the active site CP with the CR dimer [74]
Prdx2 1QMV SO2H S-sulfinylation of the active site CP decamer [75]
Prdx2 5IJT SS Oxidation/disulfide formation of the active site active site CP with the CR decamer [59]
Prdx3
S78C 		5UCX SH 3 ring stack (HMW) form dodecamer [76]
Prdx3 5JCG SH 3 ring stack (HMW) form 36-mer (3 stacked dodecamers) [76]
Prdx4 C51A 3TJG SS-like Active site resembles SS despite CP mutation decamer [70]
Prdx4 C245A 3TJJ SOH S-sulfenylation of the active site CP decamer [70]
Prdx4 3TKQ Mixed SOH and SO2H S-sulfenylation/sulfinylation of the active site CP decamer [69]
Prdx4 3TJB SS Oxidation/disulfide formation of the active site CP with the CR decamer [70]
Prdx4 C-term 3W8J – C-term only of Prdx4 in complex with P5 a0 monomer [77]
Prdx4 C-term 3WGX – C-term only in complex with ERp46 Trx2 monomer [78]
Prdx4
T118E/C14S/C87S 		5HQP SS CR in disulfide with Cys29 of ERp44 hetero tetramer [79]
Prdx4 4RQX SS Disulfide between C124 and BNP7787 (MESNA) decamer [80]
Prdx5 C72S 2VL9 SS (some SH) Oxidation/disulfide formation of the active site CP with the CR dimer [81]
Prdx5 C72S 2VL3 SS (some SH) Oxidation/disulfide formation of the active site CP with the CR dimer [81]
Prdx5 C72S 2VL2 SS (some SH) Oxidation/disulfide formation of the active site CP with the CR dimer [81]
Prdx5 3MNG with oxidized DTT bound in active site dimer [82]
Prdx5 4K7I – with an analogous fragment based on DTT (3MNG structure) dimer [83]
Prdx5 4K7N – with an analogous fragment based on DTT (3MNG structure) dimer [83]
Prdx5 4K7O – with an analogous fragment based on DTT (3MNG structure) dimer [83]
Prdx5 4MMM – withan analogous fragment based on DTT (3MNG structure) dimer [83]
Prdx5 1OC3 SS Oxidation/disulfide formation of the active site CP with the CR dimer [84]
Prdx5
C47S 		1URM – Benzoate ion in active site dimer [85]
Prdx6 5B6N SOH S-sulfenylation of the active site CP dimer [71]
Prdx6 C91S 1PRX SOH S-sulfenylation of the active site CP dimer [86]