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Lipidomics analysis showed that EKODE was among the most dramatically increased lipids in the colon of AOM/DSS-induced CRC mice. A, LC-MS/MS profiling of bioactive lipids in the colon, the Y-axis is expressed as relative change of lipid metabolite in the colon of AOM/DSS-induced CRC mice (n = 10 mice per group) vs. control mice (n = 6 mice per group). B, Structures and biosynthetic scheme of 13-HoTrE, epoxygenated fatty acids (using EpOME as an example), and EKODE.
