Fig. 2.

Oxidative stress and EKODE are increased in the colon of AOM/DSS-induced CRC mice. A, Scheme of animal experiment. B, Quantification of colon tumor in mice (n = 7–8 mice per group). C, H&E histology and IHC staining of PCNA and β-catenin in colon (n = 7 mice per group, scale bars: 50 μm). D, Concentration of EKODE in colon (n = 6–7 mice per group). E, Gene expression of Sod1, Cat, Gsr, Gsta1, Gstm1, Hmox1 and Mpo in colon (n = 6–7 mice per group). The results are mean ± SEM. The statistical significance of two groups was determined using Student's t-test or Wilcoxon-Mann-Whitney test.